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Experimentally Dissecting the Origins of Peroxiredoxin Catalysis.

Antioxidants & redox signaling - 1 Mar 2018

Nelson Kimberly J, Perkins Arden, Van Swearingen Amanda E D, Hartman Steven, Brereton Andrew E, Parsonage Derek, Salsbury Freddie R, Karplus P Andrew, Poole Leslie B

Abstract excerpt

AIMS: Peroxiredoxins (Prxs) are ubiquitous cysteine-based peroxidases involved in oxidant defense and signal transduction. Despite much study, the precise roles of conserved residues remain poorly defined. In this study, we carried out extensive functional and structural characterization of 10 variants of such residues in a model decameric bacterial Prx. RESULTS: Three active site proximal mutations of Salmonella...

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Source

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Identifiers

PMID: 28375740
DOI: 10.1089/ars.2016.6922
PMCID: PMC5806077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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