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Article

Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model.

Molecular cancer therapeutics - 1 Sept 2002

Shi Fushun, Rakhmilevich Alexander L, Heise Chuck P, Oshikawa Katsuhisa, Sondel Paul M, Yang Ning-Sun, Mahvi David M

Abstract excerpt

Effective eradication of established tumors and generation of a lasting systemic immune response is an important goal for cancer gene immunotherapy. The method of gene delivery may also be critical for the generation of an effective antitumor response. We compared the level of transgene expression and antitumor activity of two different interleukin (IL)-12 DNA preparations (naked DNA versus DNA lipid complex)....

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PMID: 12481417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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