Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.

Human immunology - 1 Jul 2011

Alcaraz-García María José, Ruiz-Lafuente Natalia, Sebastián-Ruiz Silvia, Majado María Juliana, González-García Consuelo, Bernardo María Victoria, Alvarez-López María Rocío, Parrado Antonio

Abstract excerpt

DOCK10 is a member of the dedicator of cytokinesis (DOCK) family of Rho GTPase activators preferentially expressed in lymphocytes. In this paper, we analyzed DOCK10 mRNA diversity produced because of alternative splicing. Alternative first coding exon usage led to 2 main protein-coding transcripts, DOCK10.1 and DOCK10.2. Full-length cDNA clones of both isoforms were obtained from both normal human peripheral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Guanine Nucleotide Exchange Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to HL-60 Cells

Share to Immunologic Factors

Share to Interleukin-4

Share to Jurkat Cells

Share to K562 Cells

Source

Identifiers

PMID: 21514340
DOI: 10.1016/j.humimm.2011.03.024

Genes

DOCK10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.PMID 21514340Read ↗

The regulation of DOCK family proteins on T and B cellsSemantic proximity Read ↗

DOCK family proteins: key players in immune surveillance mechanismsSemantic proximity Read ↗

Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscapeSemantic proximity Read ↗

Immune regulatory functions of DOCK family proteins in health and disease.Semantic proximity Read ↗

Alternatively Spliced Dual-Coding Regions Contribute to the Human Gene Regulatory ProgramSemantic proximity Read ↗

High expression of dedicator of cytokinesis 1 (DOCK1) confers poor prognosis in acute myeloid leukemiaSemantic proximity Read ↗

DOCK8 deficiency due to a deep intronic variant in two kindreds with hyper-IgE syndrome.Semantic proximity Read ↗

Advances in Thymosin β10 Research: Differential Expression, Molecular Mechanisms, and Clinical Implications in Cancer and Other ConditionsSemantic proximity Read ↗

RBM10: Structure, functions, and associated diseases.Semantic proximity Read ↗

Homozygous deletion and reduced expression of the DOCK8 gene in human lung cancerSemantic proximity Read ↗

PTBP2-Mediated Alternative Splicing of IRF9 Controls Tumor-Associated Monocyte/Macrophage Chemotaxis and Repolarization in Neuroblastoma ProgressionSemantic proximity Read ↗

Systemic Inflammation and Normocytic Anemia in DOCK11 DeficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.