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Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency

21 Jun 2023

Abstract excerpt

Increasing evidence links genetic defects affecting actin-regulatory proteins to diseases with severe autoimmunity and autoinflammation, yet the underlying molecular mechanisms are poorly understood. Dedicator of cytokinesis 11 (DOCK11) activates the small Rho guanosine triphosphatase (GTPase) cell division cycle 42 (CDC42), a central regulator of actin cytoskeleton dynamics. The role of DOCK11 in human...

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PMID: 37342957
DOI: 10.1056/nejmoa2210054

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