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Article

Sequential mechanism of assembly of multidrug efflux pump AcrAB-TolC.

Chemistry & biology - 22 Apr 2011

Tikhonova Elena B, Yamada Yoichi, Zgurskaya Helen I

Abstract excerpt

Multidrug efflux pumps adversely affect both the clinical effectiveness of existing antibiotics and the discovery process to find new ones. In this study, we reconstituted and characterized by surface plasmon resonance the assembly of AcrAB-TolC, the archetypal multidrug efflux pump from Escherichia coli. We report that the periplasmic AcrA and the outer membrane channel TolC assemble high-affinity complexes with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21513882
DOI: 10.1016/j.chembiol.2011.02.011
PMCID: PMC3082741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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