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Article

Rearrangement of N-Terminal α-Helices of Bacillus thuringiensis Cry1Ab Toxin Essential for Oligomer Assembly and Toxicity.

Toxins - 8 Oct 2020

Pacheco Sabino, Quiliche Jean Piere Jesus, Gómez Isabel, Sánchez Jorge, Soberón Mario, Bravo Alejandra

Abstract excerpt

Cry proteins produced by Bacillus thuringiensis are pore-forming toxins that disrupt the membrane integrity of insect midgut cells. The structure of such pore is unknown, but it has been shown that domain I is responsible for oligomerization, membrane insertion and pore formation activity. Specifically, it was proposed that some N-terminal α-helices are lost, leading to conformational changes that trigger...

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Identifiers

PMID: 33049917
DOI: 10.3390/toxins12100647
PMCID: PMC7601232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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