Article
Correct oligomerization is a prerequisite for insertion of the central molecular domain of staphylococcal alpha-toxin into the lipid bilayer.
Biochimica et biophysica acta - 14 Jun 1995
Valeva A, Palmer M, Hilgert K, Kehoe M, Bhakdi S
Abstract excerpt
Staphylococcal alpha-toxin is a primarily hydrophilic molecule that binds as a monomer to target membranes and then aggregates to form amphiphilic oligomers that represent water-filled transmembrane channels. Current evidence indicates that a region located in the center of the molecule inserts deeply into the bilayer. In the present study, we sought to determine whether membrane insertion was triggered by the...
Topics
- 2-Naphthylamine
- Arginine
- Bacterial Toxins
- Cysteine
- Fluorescent Dyes
- Hemolysin Proteins
- Lipid Bilayers
- Membrane Lipids
- Molecular Conformation
- Mutation