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Article

Mechanisms inducing low bone density in Duchenne muscular dystrophy in mice and humans.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2011

Rufo Anna, Del Fattore Andrea, Capulli Mattia, Carvello Francesco, De Pasquale Loredana, Ferrari Serge, Pierroz Dominique, Morandi Lucia, De Simone Michele, Rucci Nadia, Bertini Enrico, Bianchi Maria Luisa, De Benedetti Fabrizio, Teti Anna

Abstract excerpt

Patients affected by Duchenne muscular dystrophy (DMD) and dystrophic MDX mice were investigated in this study for their bone phenotype and systemic regulators of bone turnover. Micro-computed tomographic (µCT) and histomorphometric analyses showed reduced bone mass and higher osteoclast and bone resorption parameters in MDX mice compared with wild-type mice, whereas osteoblast parameters and mineral apposition...

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Identifiers

PMID: 21509823
DOI: 10.1002/jbmr.410
PMCID: PMC3150693

Genes

DMD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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