Article
Additional roles of a peripheral loop-loop interaction in the Neurospora VS ribozyme.
Nucleic acids research - 1 Aug 2011
DeAbreu Diane M, Olive Joan E, Collins Richard A
Abstract excerpt
Many RNAs contain tertiary interactions that contribute to folding the RNA into its functional 3D structure. In the VS ribozyme, a tertiary loop-loop kissing interaction involving stem-loops I and V is also required to rearrange the secondary structure of stem-loop I such that nucleotides at the base of stem I, which contains the cleavage-ligation site, can adopt the conformation required for activity. In the...
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