Article
NMR structure of the active conformation of the Varkud satellite ribozyme cleavage site.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003
Hoffmann Bernd, Mitchell G Thomas, Gendron Patrick, Major Francois, Andersen Angela A, Collins Richard A, Legault Pascale
Abstract excerpt
Substrate cleavage by the Neurospora Varkud satellite (VS) ribozyme involves a structural change in the stem-loop I substrate from an inactive to an active conformation. We have determined the NMR solution structure of a mutant stem-loop I that mimics the active conformation of the cleavage site internal loop. This structure shares many similarities, but also significant differences, with the previously...
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