Article
Rearrangement of substrate secondary structure facilitates binding to the Neurospora VS ribozyme.
Journal of molecular biology - 13 Dec 2002
Zamel Ricardo, Collins Richard A
Abstract excerpt
The Neurospora VS ribozyme differs from other small, naturally occurring ribozymes in that it recognizes for trans cleavage or ligation a substrate that consists largely of a stem-loop structure. We have previously found that cleavage or ligation by the VS ribozyme requires substantial rearrangem...
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