Article
Search for genetic variants in the ryanodine receptor 1 gene in patients with symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage.
Neurocritical care - 1 Dec 2011
Rueffert Henrik, Gumplinger Anja, Renner Christof, Dengl Markus, Reske Andreas, Kaisers Udo X, Meixensberger Jürgen
Abstract excerpt
BACKGROUND: Cerebral vasospasm is one of the most serious complications after subarachnoid hemorrhage (SAH). The cerebral artery diameter is regulated by complex physiological mechanisms. Among them the regulation of intracellular calcium homeostasis seems to play a crucial role. Recent data suggest that ryanodine receptors (RYRs) are involved in regulating the luminal calcium concentration in vascular smooth...
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