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Article

High prevalence of rare ryanodine receptor type 1 variants in patients suffering from aneurysmatic subarachnoid hemorrhage: A pilot study.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Nov 2017

Coburger Jan, Kapapa Thomas, Wirtz Cristian Rainer, Jurkat-Rott Karin, Klingler Werner

Abstract excerpt

Subarachnoid hemorrhage (SAH) remains a challenging neurosurgical disease. The ryanodine receptor type 1 Ca2+ channel (RyR1) plays a crucial role in vasoconstriction and hemostasis. Mutations of the encoding gene, RYR1, are known to cause susceptibility to malignant hyperthermia (MH). Recently, a RYR1 mutation was found to be associated with abnormal bleeding times. Therefore, an assessment of the RYR1 gene might...

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Identifiers

PMID: 28750945
DOI: 10.1016/j.jocn.2017.06.029

Genes

RYR1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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