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Article

Structural Impacts of Drug-Resistance Mutations Appearing in HIV-2 Protease.

Molecules (Basel, Switzerland) - 25 Jan 2021

Laville Pierre, Petitjean Michel, Regad Leslie

Abstract excerpt

The use of antiretroviral drugs is accompanied by the emergence of HIV-2 resistances. Thus, it is important to elucidate the mechanisms of resistance to antiretroviral drugs. Here, we propose a structural analysis of 31 drug-resistant mutants of HIV-2 protease (PR2) that is an important target against HIV-2 infection. First, we modeled the structures of each mutant. We then located structural shifts putatively...

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Share to Anti-Retroviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hydrophobic and Hydrophilic Interactions

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Identifiers

PMID: 33503916
DOI: 10.3390/molecules26030611
PMCID: PMC7865771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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