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Article

Impacts of drug resistance mutations on the structural asymmetry of the HIV-2 protease.

BMC molecular and cell biology - 23 Jun 2020

Laville Pierre, Fartek Sandrine, Cerisier Natacha, Flatters Delphine, Petitjean Michel, Regad Leslie

Abstract excerpt

BACKGROUND: Drug resistance is a severe problem in HIV treatment. HIV protease is a common target for the design of new drugs for treating HIV infection. Previous studies have shown that the crystallographic structures of the HIV-2 protease (PR2) in bound and unbound forms exhibit structural asymmetry that is important for ligand recognition and binding. Here, we investigated the effects of resistance mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32576133
DOI: 10.1186/s12860-020-00290-1
PMCID: PMC7310402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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