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Article

Prediction of mutational tolerance in HIV-1 protease and reverse transcriptase using flexible backbone protein design.

PLoS computational biology - 1 Jan 2012

Humphris-Narayanan Elisabeth, Akiva Eyal, Varela Rocco, Ó Conchúir Shane, Kortemme Tanja

Abstract excerpt

Predicting which mutations proteins tolerate while maintaining their structure and function has important applications for modeling fundamental properties of proteins and their evolution; it also drives progress in protein design. Here we develop a computational model to predict the tolerated seq...

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Identifiers

PMID: 22927804
DOI: 10.1371/journal.pcbi.1002639
PMCID: PMC3426558

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22927804-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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