Article
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Nature - 12 May 2011
Guarani Virginia, Deflorian Gianluca, Franco Claudio A, Krüger Marcus, Phng Li-Kun, Bentley Katie, Toussaint Louise, Dequiedt Franck, Mostoslavsky Raul, Schmidt Mirko H H, Zimmermann Barbara, Brandes Ralf P, Mione Marina, Westphal Christoph H, Braun Thomas, Zeiher Andreas M, Gerhardt Holger, Dimmeler Stefanie, Potente Michael
Abstract excerpt
Notch signalling is a key intercellular communication mechanism that is essential for cell specification and tissue patterning, and which coordinates critical steps of blood vessel growth. Although subtle alterations in Notch activity suffice to elicit profound differences in endothelial behaviour and blood vessel formation, little is known about the regulation and adaptation of endothelial Notch responses. Here...
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