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Article

A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.

Molecular cell - 10 Jun 2011

Mulligan Peter, Yang Fajun, Di Stefano Luisa, Ji Jun-Yuan, Ouyang Jian, Nishikawa Joy L, Toiber Debra, Kulkarni Madhura, Wang Qun, Najafi-Shoushtari S Hani, Mostoslavsky Raul, Gygi Steven P, Gill Grace, Dyson Nicholas J, Näär Anders M

Abstract excerpt

Epigenetic regulation of gene expression by histone-modifying corepressor complexes is central to normal animal development. The NAD(+)-dependent deacetylase and gene repressor SIRT1 removes histone H4K16 acetylation marks and facilitates heterochromatin formation. However, the mechanistic contribution of SIRT1 to epigenetic regulation at euchromatic loci and whether it acts in concert with other...

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Identifiers

PMID: 21596603
DOI: 10.1016/j.molcel.2011.04.020
PMCID: PMC3119599

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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