Article
Comparative activities of selected fluoroquinolones against dynamic populations of Actinobacillus pleuropneumoniae in an in vitro model of time-kill continuous culture experiment.
International journal of antimicrobial agents - 1 Dec 2013
Damte Dereje, Lee Seung-Jin, Yohannes Sileshi B, Hossain Md Akil, Suh Joo-Won, Park Seung-Chun
Abstract excerpt
The aim of the current study was to demonstrate and compare the impact of different pharmacokinetics of marbofloxacin, enrofloxacin and difloxacin on their antimicrobial effects, their killing and re-growth kinetics, and the population dynamics of Actinobacillus pleuropneumoniae clinical isolates in an in vitro dynamic model. Selected clinical isolates of A. pleuropneumoniae and three fluoroquinolones at a range...
Topics
- Actinobacillus pleuropneumoniae
- Anti-Bacterial Agents
- DNA, Bacterial
- Fluoroquinolones
- Models, Theoretical
- Molecular Sequence Data
- Mutation
- Selection, Genetic
- Sequence Analysis, DNA