Article
Methylenetetrahydrofolate reductase polymorphism C677T is a protective factor for pediatric acute lymphoblastic leukemia in the Chinese population: a meta-analysis.
Genetic testing and molecular biomarkers - 1 Dec 2012
Wang Haigang, Meng Lujing, Zhao Lixia, Wang Jiali, Liu Xinchun, Mi Wenjie
Abstract excerpt
Two polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, were hypothesized to decrease the risk of acute lymphoblastic leukemia (ALL). Studies examining the associations between these two polymorphisms and ALL susceptibility drew inconsistent results. To obtain a reliable conclusion in a Chinese population, we carried out a meta-analysis. In total, 11 studies on C677T...
Topics
- Adult
- Asian People
- Child
- Confidence Intervals
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)