Article
Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia.
American journal of hematology - 1 Jul 2014
Walsh Kyle M, de Smith Adam J, Welch Tara C, Smirnov Ivan, Cunningham Marc J, Ma Xiaomei, Chokkalingam Anand P, Dahl Gary V, Roberts William, Barcellos Lisa F, Buffler Patricia A, Metayer Catherine, Wiemels Joseph L
Abstract excerpt
Hispanic children have a higher incidence of acute lymphoblastic leukemia (ALL) than non-Hispanic whites but tend to be diagnosed at older ages. In genome-wide association studies, Native American ancestry and polymorphisms in six genes have been associated with ALL risk. In multivariable regression models, we investigated whether genomic ancestry, inherited risk SNPs, or acquired somatic alterations were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.