Article
Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same individual.
Nucleic acids research - 1 Aug 2011
Galante Pedro A F, Parmigiani Raphael B, Zhao Qi, Caballero Otávia L, de Souza Jorge E, Navarro Fábio C P, Gerber Alexandra L, Nicolás Marisa F, Salim Anna Christina M, Silva Ana Paula M, Edsall Lee, Devalle Sylvie, Almeida Luiz G, Ye Zhen, Kuan Samantha, Pinheiro Daniel G, Tojal Israel, Pedigoni Renato G, de Sousa Rodrigo G M A, Oliveira Thiago Y K, de Paula Marcelo G, Ohno-Machado Lucila, Kirkness Ewen F, Levy Samuel, da Silva Wilson A, Vasconcelos Ana Tereza R, Ren Bing, Zago Marco Antonio, Strausberg Robert L, Simpson Andrew J G, de Souza Sandro J, Camargo Anamaria A
Abstract excerpt
Although patterns of somatic alterations have been reported for tumor genomes, little is known on how they compare with alterations present in non-tumor genomes. A comparison of the two would be crucial to better characterize the genetic alterations driving tumorigenesis. We sequenced the genomes of a lymphoblastoid (HCC1954BL) and a breast tumor (HCC1954) cell line derived from the same patient and compared the...
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