Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Somatic alterations in the human cancer genome.

Cancer cell - 1 Nov 2004

Weir Barbara, Zhao Xiaojun, Meyerson Matthew

Abstract excerpt

Most human malignancies are caused by somatic alterations within the cancer genome, leading to oncogene activation or tumor suppressor gene inactivation. The sequence of the human genome has enabled systematic approaches to identify cancer genome alterations, including point mutations, copy number increases and decreases, loss of allelic heterozygosity, and chromosome translocations. Systematic cancer genome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Chromosome Aberrations
Share to BRAF gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Genome, Human

Share to Multigene Family

Share to Mutation

Share to Neoplasms

Source

Identifiers

PMID: 15542426
DOI: 10.1016/j.ccr.2004.11.004

Genes

BRAF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Somatic alterations in the human cancer genome.PMID 15542426Read ↗

Our changing view of the genomic landscape of cancer.Semantic proximity Read ↗

Catalogue, cause, complexity and cure; the many uses of cancer genome sequence.Semantic proximity Read ↗

Patterns of somatic mutation in human cancer genomes.Semantic proximity Read ↗

COSMIC: High-Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer.Semantic proximity Read ↗

A fresh look at somatic mutations in cancer.Semantic proximity Read ↗

Somatic mutation in cancer and normal cells.Semantic proximity Read ↗

COSMIC: exploring the world's knowledge of somatic mutations in human cancer.Semantic proximity Read ↗

Mutational landscape and significance across 12 major cancer types.Semantic proximity Read ↗

The cancer genome.Semantic proximity Read ↗

Unraveling the genetics of cancer: genome sequencing and beyond.Semantic proximity Read ↗

Somatic Mutation Events Were Characterized Across the Whole Cancer Genome.Semantic proximity Read ↗

Exploring the genomes of cancer cells: progress and promise.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.