Article
A comprehensive catalogue of somatic mutations in cancer genomes.
DNA repair - 4 Apr 2010
Friedberg Errol C
Abstract excerpt
This Hot Topics contribution considers two recently published papers that demonstrate the utility of advanced DNA sequencing technologies for identifying classes of mutations other than base substitutions. Data are presented from genome analyses of immortalized cell lines derived from a malignant melanoma and a small cell carcinoma of the lung. Among other observations the studies suggest the operation of novel...
Topics
- Carcinoma, Small Cell
- Genome, Human
- Humans
- Lung Neoplasms
- Mutation
- Neoplasms
