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Article

Relationship Between Genetic Polymorphisms in Cell Cycle Regulatory Gene TP53 and Polycystic Ovarian Syndrome: A Case-Control Study and In Silico Analyses.

Biochemical genetics - 1 Oct 2023

Biglari-Zadeh Ghazaleh, Sargazi Saman, Mohammadi Malihe, Ghasemi Marzieh, Majidpour Mahdi, Saravani Ramin, Mirinejad Shekoufeh

Abstract excerpt

Polycystic ovarian syndrome (PCOS) is a complex endocrine and metabolic condition with several potential causes. Insulin resistance is a hallmark of PCOS that often coexists with hirsutism, hyperandrogenism, being overweight, and hormonal imbalances. The functioning of multiple replication and transcription factors is regulated by tumor suppressor genes (TSGs), which play a crucial role in maintaining genomic...

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PMID: 36856940
DOI: 10.1007/s10528-023-10349-1

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