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Article

PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer.

Molecular cancer therapeutics - 1 Jun 2011

Gonzalez-Angulo Ana M, Ferrer-Lozano Jaime, Stemke-Hale Katherine, Sahin Aysegul, Liu Shuying, Barrera Juan A, Burgues Octavio, Lluch Ana M, Chen Huiqin, Hortobagyi Gabriel N, Mills Gordon B, Meric-Bernstam Funda

Abstract excerpt

The purpose of this work was to determine whether there are differences in PIK3CA mutation status and PTEN protein expression between primary and matched metastatic breast tumors as this could influence patient management. Paraffin sections of 50 μm were used for DNA extraction and slides of 3 μm for immunohistochemistry (IHC) and FISH. Estrogen receptor, progesterone receptor, and HER2 IHC were repeated in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

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Share to PTEN Phosphohydrolase

Share to Receptor, ErbB-2

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Source

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Identifiers

PMID: 21490305
DOI: 10.1158/1535-7163.MCT-10-1089
PMCID: PMC3112276

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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