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Article

PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2007

Pérez-Tenorio Gizeh, Alkhori Liza, Olsson Birgit, Waltersson Marie Ahnström, Nordenskjöld Bo, Rutqvist Lars Erik, Skoog Lambert, Stål Olle

Abstract excerpt

PURPOSE: The phosphatidylinositol 3'-kinase/Akt pathway is frequently altered in breast cancer. PTEN, a phosphatase that opposes the effect of phosphatidylinositol 3'-kinase, can be mutated or lost, whereas the PIK3CA gene is mutated. These have been proposed as alternative mechanisms, and their clinicalpathology significance is under discussion. In this study, we aimed to explore whether PIK3CA mutations and...

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PMID: 17575221
DOI: 10.1158/1078-0432.CCR-06-1609

Genes

PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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