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Article

PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2007

Pérez-Tenorio Gizeh, Alkhori Liza, Olsson Birgit, Waltersson Marie Ahnström, Nordenskjöld Bo, Rutqvist Lars Erik, Skoog Lambert, Stål Olle

Abstract excerpt

PURPOSE: The phosphatidylinositol 3'-kinase/Akt pathway is frequently altered in breast cancer. PTEN, a phosphatase that opposes the effect of phosphatidylinositol 3'-kinase, can be mutated or lost, whereas the PIK3CA gene is mutated. These have been proposed as alternative mechanisms, and their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17575221
DOI: 10.1158/1078-0432.CCR-06-1609

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17575221-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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