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Article

From resistance to stimulation: the evolution of a virus in the presence of a dominant lethal inhibitory scaffolding protein.

Journal of virology - 1 Jul 2011

Cherwa James E, Fane Bentley A

Abstract excerpt

By acquiring resistance to an inhibitor, viruses can become dependent on that inhibitor for optimal fitness. However, inhibitors rarely, if ever, stimulate resistant strain fitness to values that equal or exceed the uninhibited wild-type level. This would require an adaptive mechanism that converts the inhibitor into a beneficial replication factor. Using a plasmid-encoded inhibitory external scaffolding protein...

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Share to Bacteriophage phi X 174
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21490088
DOI: 10.1128/JVI.00261-11
PMCID: PMC3126481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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