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Article

HLA-DRB1 reduces the risk of type 2 diabetes mellitus by increased insulin secretion.

Diabetologia - 1 Jul 2011

Williams R C, Muller Y L, Hanson R L, Knowler W C, Mason C C, Bian L, Ossowski V, Wiedrich K, Chen Y F, Marcovina S, Hahnke J, Nelson R G, Baier L J, Bogardus C

Abstract excerpt

AIMS/HYPOTHESIS: We sought to identify the physiological implications of genetic variation at the HLA-DRB1 region in full-heritage Pima Indians in Arizona. METHODS: Single-nucleotide polymorphisms from the HLA region on chromosome 6p were tested for association with skeletal muscle mRNA expression of HLA-DRB1 and HLA-DRA, and with type 2 diabetes mellitus and prediabetic traits. RESULTS: The A allele at...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 21484216
DOI: 10.1007/s00125-011-2122-8
PMCID: PMC6432927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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