Article
Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.
Diabetic medicine : a journal of the British Diabetic Association - 1 Aug 2014
Guigas B, de Leeuw van Weenen J E, van Leeuwen N, Simonis-Bik A M, van Haeften T W, Nijpels G, Houwing-Duistermaat J J, Beekman M, Deelen J, Havekes L M, Penninx B W J H, Vogelzangs N, van 't Riet E, Dehghan A, Hofman A, Witteman J C, Uitterlinden A G, Grarup N, Jørgensen T, Witte D R, Lauritzen T, Hansen T, Pedersen O, Hottenga J, Romijn J A, Diamant M, Kramer M H H, Heine R J, Willemsen G, Dekker J M, Eekhoff E M, Pijl H, de Geus E J, Slagboom P E, 't Hart L M
Abstract excerpt
AIMS: Modulation of dopamine receptor D2 (DRD2) activity affects insulin secretion in both rodents and isolated pancreatic β-cells. We hypothesized that single nucleotide polymorphisms in the DRD2/ANKK1 locus may affect susceptibility to type 2 diabetes in humans. METHODS: Four potentially functional variants in the coding region of the DRD2/ANKK1 locus (rs1079597, rs6275, rs6277, rs1800497) were genotyped and...