Article
Type 1 diabetes susceptibility determined by HLA alleles and CTLA-4 and insulin genes polymorphisms in Brazilians.
Arquivos brasileiros de endocrinologia e metabologia - 1 Apr 2009
Ferreira Alessandro Clayton Souza, Gomes Karina Braga, Sampaio Ivan Barbosa Machado, Oliveira Vanessa Cristina de, Pardini Victor Cavalcanti, Godard Ana Lucia Brunialti
Abstract excerpt
INTRODUCTION: Type 1A diabetes mellitus (T1ADM) is a multifactorial disease in which genetic and environmental aspects are important to its development. The association of genetic variations with disease has been demonstrated in several studies; however, the role of some gene loci has not yet been fully elucidated. OBJECTIVE: To compare the frequency of HLA alleles and polymorphism in CTLA-4 and insulin genes in...
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