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Article

Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.

European journal of endocrinology - 1 Jul 2012

Andersen Mette K, Lundgren Virve, Isomaa Bo, Groop Leif, Tuomi Tiinamaija

Abstract excerpt

OBJECTIVE: Previously, we observed an association between family history of type 1 diabetes and development of non-insulin-dependent diabetes. The aims of this study were to assess whether type 1 diabetes susceptibility gene variants explain this association and investigate the effect of the variants on insulin secretion and presence of glutamic acid decarboxylase autoantibodies (GADA) in nondiabetic adults....

Read the complete abstract on PubMed

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Share to Autoantibodies
Share to CTLA-4 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus

Share to Glutamate Decarboxylase

Share to HLA-DQ alpha-Chains

Share to HLA-DQ beta-Chains

Share to Insulin Secretion

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 22

Source

Identifiers

PMID: 22511809
DOI: 10.1530/EJE-12-0023

Genes

PTPN22
CTLA4
INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.PMID 22511809Read ↗

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