Article
HLA-A gene variation modulates residual function of the pancreatic β-cells in children with type 1 diabetes.
Pediatric endocrinology, diabetes, and metabolism - 1 Jan 2020
Hogendorf Anna, Abel Michał, Wyka Krystyna, Bodalski Jerzy, Młynarski Wojciech
Abstract excerpt
AIM OF THE STUDY: The study aimed to analyze an association between the HLA-A gene variation and a risk of type 1 diabetes development and to evaluate the association of HLA class I and class II alleles with β-cell destruction. MATERIAL AND METHODS: A group of 108 children with type 1 diabetes were genotyped in HLA-A, -DRB1, and -DQB1 genes using hybridization with oligonu-cleotides probes. Plasma C-peptide...
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