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Article

DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription.

PloS one - 31 Mar 2011

Zamudio Natasha M, Scott Hamish S, Wolski Katja, Lo Chi-Yi, Law Charity, Leong Dillon, Kinkel Sarah A, Chong Suyinn, Jolley Damien, Smyth Gordon K, de Kretser David, Whitelaw Emma, O'Bryan Moira K

Abstract excerpt

Previous studies on the epigenetic regulator DNA methyltransferase 3-Like (DNMT3L), have demonstrated it is an essential regulator of paternal imprinting and early male meiosis. Dnmt3L is also a paternal effect gene, i.e., wild type offspring of heterozygous mutant sires display abnormal phenotypes suggesting the inheritance of aberrant epigenetic marks on the paternal chromosomes. In order to reveal the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21483837
DOI: 10.1371/journal.pone.0018276
PMCID: PMC3069080

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