A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9.

doi:10.1016/j.biopsych.2007.11.005

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Article

A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9.

Biological psychiatry - 1 Jun 2008

Dick Danielle M, Aliev Fazil, Wang Jen C, Saccone Scott, Hinrichs Anthony, Bertelsen Sarah, Budde John, Saccone Nancy, Foroud Tatiana, Nurnberger John, Xuei Xiaoling, Conneally P M, Schuckit Marc, Almasy Laura, Crowe Raymond, Kuperman Samuel, Kramer John, Tischfield Jay A, Hesselbrock Victor, Edenberg Howard J, Porjesz Bernice, Rice John P, Bierut Laura, Goate Alison

Abstract excerpt

BACKGROUND: Chromosome 7 has shown consistent evidence of linkage with a variety of phenotypes related to alcohol dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) project. With a sample of 262 densely affected families, a peak logarithm of odds (LOD) score for alcohol dependence of 2.9 was observed at D7S1799. The LOD score in the region increased to 4.1 when a subset of the sample was...

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PMID: 18163977
DOI: 10.1016/j.biopsych.2007.11.005
PMCID: PMC3823371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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