Article
Cirrhosis and rapid virological response to peginterferon plus ribavirin determine treatment outcome in HCV-1 IL28B rs12979860 CC patients.
BioMed research international - 1 Jan 2013
Aghemo Alessio, Degasperi Elisabetta, Rumi Maria Grazia, Galmozzi Enrico, Valenti Luca, De Francesco Raffaele, De Nicola Stella, Cheroni Cristina, Grassi Eleonora, Colombo Massimo
Abstract excerpt
BACKGROUND: The rs12979860 CC genotype of the interleukin 28B (IL28B) polymorphism is associated with high rates of sustained virological response (SVR) to peginterferon (PegIFN) and ribavirin (Rbv) in hepatitis C virus genotype-1 (HCV-1) patients. The impact of baseline predictors of treatment outcome and their interplay with viral kinetics in HCV-1 CC patients has not been fully evaluated. AIM: To identify...
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