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Article

Centromere fission, not telomere erosion, triggers chromosomal instability in human carcinomas

8 Apr 2011

Abstract excerpt

The majority of sporadic carcinomas suffer from a kind of genetic instability in which chromosome number changes occur together with segmental defects. This means that changes involving intact chromosomes accompany breakage-induced alterations. Whereas the causes of aneuploidy are described in detail, the origins of chromosome breakage in sporadic carcinomas remain disputed. The three main pathways of chromosomal...

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Share to Chromosomal and Genetic Variations
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Share to Telomeres, Telomerase, and Senescence

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PMID: 21478459
DOI: 10.1093/carcin/bgr069

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