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Article

Study of arachidonoyl specificity in two enzymes of the PI cycle.

Journal of molecular biology - 3 Jun 2011

Shulga Yulia V, Topham Matthew K, Epand Richard M

Abstract excerpt

We identified a conserved pattern of residues L-X((3-4))-R-X((2))-L-X((4))-G, in which -X((n))- is n residues of any amino acid, in two enzymes acting on the polyunsaturated fatty acids, diacylglycerol kinase epsilon (DGKɛ) and phosphatidylinositol-4-phosphate-5-kinase Iα (PIP5K Iα). DGKɛ is the only one of the 10 mammalian isoforms of DGK that exhibits arachidonoyl specificity and is the only isoform with the...

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Identifiers

PMID: 21477596
DOI: 10.1016/j.jmb.2011.03.071
PMCID: PMC3095698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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