Article
Amino acids determining enzyme-substrate specificity in prokaryotic and eukaryotic protein kinases.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2003
Li Lewyn, Shakhnovich Eugene I, Mirny Leonid A
Abstract excerpt
The binding between a PK and its target is highly specific, despite the fact that many different PKs exhibit significant sequence and structure homology. There must be, then, specificity-determining residues (SDRs) that enable different PKs to recognize their unique substrate. Here we use and further develop a computational procedure to discover putative SDRs (PSDRs) in protein families, whereby a family of...
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