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Article

An intact zinc finger motif of the C1B domain is critical for stability and activity of diacylglycerol kinase-ε.

The international journal of biochemistry & cell biology - 1 Nov 2022

Traczyk Gabriela, Świątkowska Anna, Hromada-Judycka Aneta, Janikiewicz Justyna, Kwiatkowska Katarzyna

Abstract excerpt

Diacylglycerol kinase-ε (DGKε) phosphorylates DAG to phosphatidic acid with unique specificity toward 18:0/20:4 DAG (SAG). SAG is a typical backbone of phosphatidylinositol and its derivatives, therefore DGKε activity is crucial for the turnover of these signaling lipids. Malfunction of DGKε contributes to several pathophysiological conditions, including atypical hemolytic uremic syndrome (aHUS) linked with DGKE...

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Identifiers

PMID: 36113832
DOI: 10.1016/j.biocel.2022.106295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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