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Cancer-associated fibroblasts in early-stage lung adenocarcinoma correlate with tumor aggressiveness

17 Oct 2023

Abstract excerpt

Abstract Lung adenocarcinoma (LUAD) is the predominant type of lung cancer in the U.S. and exhibits a broad variety of behaviors ranging from indolent to aggressive. Identification of the biological determinants of LUAD behavior at early stages can improve existing diagnostic and treatment strategies. Extracellular matrix (ECM) remodeling and cancer-associated fibroblasts play a crucial role in the regulation of...

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PMID: 37848457
DOI: 10.1038/s41598-023-43296-3

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