Article
Night blindness and the mechanism of constitutive signaling of mutant G90D rhodopsin.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Nov 2008
Dizhoor Alexander M, Woodruff Michael L, Olshevskaya Elena V, Cilluffo Marianne C, Cornwall M Carter, Sieving Paul A, Fain Gordon L
Abstract excerpt
The G90D rhodopsin mutation is known to produce congenital night blindness in humans. This mutation produces a similar condition in mice, because rods of animals heterozygous (D+) or homozygous (D+/+) for this mutation have decreased dark current and sensitivity, reduced Ca(2+), and accelerated values of tau(REC) and tau(D), similar to light-adapted wild-type (WT) rods. Our experiments indicate that G90D pigment...
Topics
- Animals
- Aspartic Acid
- Calcium
- Carrier Proteins
- Dark Adaptation
- Disease Models, Animal
- Dose-Response Relationship, Radiation
- Eye Proteins
- Glycine
- Kinetics