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Article

Effect of fibrinogen concentration and platelet count on the inhibitory effect of abciximab and tirofiban.

Thrombosis and haemostasis - 1 Feb 2003

Renda Giulia, Rocca Bianca, Crocchiolo Roberto, Cristofaro Raimondo De, Landolfi Raffaele

Abstract excerpt

Glycoprotein (Gp) IIb/IIIa blockers are powerful antithrombotic agents, but display a wide variability of their effect using weight adjusted dosing. We investigated whether some hemostatic variables affected in vitro platelet inhibition exerted by the antibody abciximab and the peptidomimetic tirofiban. High fibrinogen concentrations reduced platelet inhibition by tirofiban, assessed in whole blood (r = -0.85, n...

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Source

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PMID: 12574816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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