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Article

MicroRNAs Dynamically Remodel Gastrointestinal Smooth Muscle Cells

14 Apr 2011

Abstract excerpt

Smooth muscle cells (SMCs) express a unique set of microRNAs (miRNAs) which regulate and maintain the differentiation state of SMCs. The goal of this study was to investigate the role of miRNAs during the development of gastrointestinal (GI) SMCs in a transgenic animal model. We generated SMC-specific Dicer null animals that express the reporter, green fluorescence protein, in a SMC-specific manner. SMC-specific...

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PMID: 21533178
DOI: 10.1371/journal.pone.0018628

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