Article
A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Apr 2011
Boersma Matthew C H, Dresselhaus Erica C, De Biase Lindsay M, Mihalas Anca B, Bergles Dwight E, Meffert Mollie K
Abstract excerpt
Structural plasticity of dendritic spines and synapses is a fundamental mechanism governing neuronal circuits and may form an enduring basis for information storage in the brain. We find that the p65 subunit of the nuclear factor-κB (NF-κB) transcription factor, which is required for learning and memory, controls excitatory synapse and dendritic spine formation and morphology in murine hippocampal neurons....
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