Article
TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers.
Molecular medicine reports - 1 Jan 2000
Sonoyama Takayuki, Sakai Akiko, Mita Yuichiro, Yasuda Yukiko, Kawamoto Hirofumi, Yagi Takahito, Yoshioka Masao, Mimura Tetsushige, Nakachi Kei, Ouchida Mamoru, Yamamoto Kazuhide, Shimizu Kenji
Abstract excerpt
Tumor protein p53 (TP53) is the best-known tumor suppressor gene and plays a crucial role in carcinogenesis. The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated. Therefore, we investigated the effects of this polymorphism on pancreatic cancer in relation to smoking and drinking habits by...
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