Article
Repetitive transgenes in C. elegans accumulate heterochromatic marks and are sequestered at the nuclear envelope in a copy-number- and lamin-dependent manner.
Cold Spring Harbor symposia on quantitative biology - 1 Jan 2010
Towbin B D, Meister P, Pike B L, Gasser S M
Abstract excerpt
Chromatin is nonrandomly distributed in nuclear space, yet the functional significance of this remains unclear. Here, we make use of transgenes carrying developmentally regulated promoters to study subnuclear gene positioning during the development of Caenorhabditis elegans. We found that small transgenes (copy number ≤50) are randomly distributed in early embryonic nuclei, independent of promoter activity....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.