Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent.

doi:10.1016/j.atherosclerosis.2011.03.008

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Article

Evaluation of the gene-age interactions in HDL cholesterol, LDL cholesterol, and triglyceride levels: the impact of the SORT1 polymorphism on LDL cholesterol levels is age dependent.

Atherosclerosis - 1 Jul 2011

Shirts Brian H, Hasstedt Sandra J, Hopkins Paul N, Hunt Steven C

Abstract excerpt

Several genes that influence HDL-C, LDL-C, and triglyceride levels have been identified. The effects of genetic polymorphisms on lipid levels may be age dependent. We replicated 17 of these previously identified associations and then used cross-sectional and longitudinal analysis to investigate age-SNP interaction effects. The rs646776 SNP at the SORT1 locus showed an age interaction that was significant in...

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Identifiers

PMID: 21466885
DOI: 10.1016/j.atherosclerosis.2011.03.008
PMCID: PMC3138874

Genes

SORT1

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