Article
The 1p13.3 LDL (C)-associated locus shows large effect sizes in young populations.
Pediatric research - 1 Jun 2011
Devaney Joseph M, Thompson Paul D, Visich Paul S, Saltarelli William A, Gordon Paul M, Orkunoglu-Suer E Funda, Gordish-Dressman Heather, Harmon Brennan T, Bradbury Margaret K, Panchapakesan Karuna, Khianey Rahul, Hubal Monica J, Clarkson Priscilla M, Pescatello Linda S, Zoeller Robert F, Moyna Niall M, Angelopoulos Theodore J, Kraus William E, Hoffman Eric P
Abstract excerpt
Genome-wide association studies (GWASs) have identified polymorphic loci associated with coronary artery disease (CAD) risk factors (i.e. serum lipids) in adult populations (42-69 y). We hypothesized that younger populations would show a greater relative genetic component due to fewer confounding variables. We examined the influence of 20 GWAS loci associated with serum lipids and insulin metabolism, in a...
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