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Article

Genetic variance components estimation for binary traits using multiple related individuals.

Genetic epidemiology - 1 Jul 2011

Papachristou Charalampos, Ober Carole, Abney Mark

Abstract excerpt

Understanding and modeling genetic or nongenetic factors that influence susceptibility to complex traits has been the focus of many genetic studies. Large pedigrees with known complex structure may be advantageous in epidemiological studies since they can significantly increase the number of factors whose influence on the trait can be estimated. We propose a likelihood approach, developed in the context of...

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Identifiers

PMID: 21465547
DOI: 10.1002/gepi.20577
PMCID: PMC3612980

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